PhD position on "On-Chip Separation of Proteins for Single-Cell Proteome Profiling"
100%, Zurich, fixed-term
The laboratory of Single-Molecule and Single-Cell Biophysics (BMC)is a research group in the Department of Information Technology and Electrical Engineering (D-ITET) at ETH Zürich led by Prof. Morteza Aramesh. We work in close collaboration with the Laboratory of Biosensors and Bioelectronics (LBB) led by Prof. Janos Vörös.
The focus of BMC group is developing technologies that enable single-cell studies down to single-molecule level. In our research, nanotechnology and biophysics meet to answer important biological questions. We're curious about things like how cells release proteins and how immune cells in our body fight against disease using their protein repertoire.
Our work has important applications, especially in understanding immune cells better and finding new ways to treat diseases using cells. Our research is focused on making sensors that can be used for monitoring process in living cells, and we're especially interested in using nanopore sensors for this purpose. These sensors help us see what's happening both inside and outside the cells. For example, we can observe how immune cells fight against cancer cells or how cells react to external physical or chemicals cues. We work closely with scientists from other disciplines such as biology and immunology, to implement our knowledge in emerging applications such as cell-based therapies to fight against cancer and other infectious diseases.
In this context, we invite applications for one PhD position to work on ERC funded project focusing on development of nanopore sensors for monitoring protein production and secretion in single cells.
Project background
Genomics revolution occurred because of the invention of single-molecule sequencing technologies, and consequently it has profoundly improved precision medicine and diagnostics. Single-cell proteomics and secretomics is on its way to make a similar groundbreaking impact on our future understanding of cells and will significantly contribute to the development of drugs and cell-based therapies.
The main objective of the ERC funded project is to pioneer research direction of in situ cell profiling by identification of proteins, their abundance and temporal distribution at a single-cell level using nanopore sensors. The approach is the first of its type that can potentially address important biology questions at single-cell level and with a much higher temporal and spatial sensitivity compared to other existing methods.
To achieve a major breakthrough in single-cell profiling technologies and pushing the boundaries of in situ proteomics and secretomics, the project is set to achieve the following goals:
Job description
Profile
Successful candidates should have
Workplace
Gloriastrasse 37/39
We offer
ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.
Working, teaching and research at ETH Zurich
We value diversity
In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.
We look forward to receiving your online application with the following documents:
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about BMC can be found on our website.
Questions regarding the position should be directed to Prof. Morteza Aramesh (maramesh@ethz.ch) (No applications).
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